pyruvate kinase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T76115	Pyruvate kinase
	Pyruvate kinase is a glycolytic enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP [1] .
T12499	PKR-IN-2		PKM
	PKR-IN-2 is a activator of pyruvate kinase (PKR).		PKM
T6816	DASA-58		PKM
	DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.		PKM
T4223	Mitapivat	PKR-IN-1	PKM
	Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.		PKM
T11765	KPLH1130		Dehydrogenase , PDK
	KPLH1130, a specific pyruvate dehydrogenase kinase (PDK) inhibitor, enhances glucose tolerance in mice fed a high-fat diet (HFD). It effectively hinders macrophage polarization and mitigates proinflammatory reactions.		Dehydrogenase , PDK
T17224	VER-246608		Dehydrogenase , PDK
	VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism an...		Dehydrogenase , PDK
T2447	AZD7545		Dehydrogenase
	AZD7545 is a potent PDHK inhibitor.		Dehydrogenase
T22350	JX06		Apoptosis , Dehydrogenase , PDK
	JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively.		Apoptosis , Dehydrogenase , PDK
T0809	Dicoumarol	Dicumarol	Dehydrogenase , NADPH , PDK
	Dicoumarol (Dicumarol) is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicoumarol is a competitive inhibitor of vitamin K epoxidereductase; t...		Dehydrogenase , NADPH , PDK
T7214	TEPP-46	ML265	PKM
	TEPP-46 (ML265) is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in a mouse xenograft model. .		PKM
T3604	Sodium dichloroacetate	Sodium Dichloroacetate,DCA,bichloroacetic acid,Sodium dichloroacetate (DCA)	Apoptosis , Dehydrogenase , Reactive Oxygen Species , PDK
	Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion chann...		Apoptosis , Dehydrogenase , Reactive Oxygen Species , PDK
T4170	PKM2-IN-1	PKM2 inhibitor,compound 3k	PKM
	PKM2-IN-1 (compound 3k) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.		PKM
T12412L	PDK4-IN-1 hydrochloride		Apoptosis , PDK
	PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4)(IC50 value of 84 nM)		Apoptosis , PDK
T19783	Dehydroabiethylamine	NSC-2955,NSC 2955,Dehydroabietylamine,NSC2955,Leelamine free base,Leelamine	P450 , PDK
	Dehydroabiethylamine (NSC-2955) is an inducer of hepatic CYP2B activity. Dehydroabiethylamine inhibits pyruvate dehydrogenase kinases (PDKs) and intracellular cholesterol transport with anti-tumor activity.		P450 , PDK
T1125	Shikonin	NSC 252844,Isoarnebin 4,(+)-Shikonin,Alkanna Red,C.I. 75535,Anchusa acid	TNF , NF-κB , Chloride channel , HIV Protease , PKM
	Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and selective PKM2 inhibitor. Shikonin exhibits antitumor, anti-inflammatory and wound healing activities.		TNF , NF-κB , Chloride channel , HIV Protease , PKM
T0745	Disodium monofluorophosphate	Sodium Monofluorophosphate,NSC248	Phosphatase , PKM , Phosphorylase
	Disodium monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase, which also irreversibly inhibits phosphorylase phosphatase.		Phosphatase , PKM , Phosphorylase
T67900	PKM2 inhibitor G		PKM
	PKM2 inhibitor G is a inhibitor of pyruvate kinase.		PKM
T8363	DL-Serine		PKM
	DL-Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.		PKM
T4898	Potassium 1-carboxyvinyl hydrogenphosphate	PEP-K,Phospho(enol)pyruvic acid monopotassium	Others , Endogenous Metabolite
	Potassium 1-carboxyvinyl hydrogenphosphate (PEP-K) is involved in glycolysis and gluconeogeneis. In glycolysis, PEP is metabolized by Pyruvate Kinase to yield pyruvate. In plants, PEP is involved in the formation of arom...		Others , Endogenous Metabolite
T15944	M77976		PDK
	M77976 is a selective ATP-competitive inhibitor of pyruvate dehydrogenase kinase 4 (PDK4) with an inhibitory effect on PDK4, having an IC50 value of 648 μM. It is used for research related to obesity and diabetes.		PDK